Phyllida Spore studied Herbology and authored One Thousand Magical Herbs and Fungi, a textbook that was still used at Hogwarts School of Witchcraft and Wizardry in 1997.
At some point in her life, she became the Headmistress of Hogwarts. Also at an unknown time, Spore received the title and honor of "dame".
Spore died in 1408. Two portraits of her hung at Hogwarts: one depicted a middle-aged woman, and another, hung in the Headmaster's office, depicted her as a younger witch with long dark hair.